New flexible, movable device with minimally invasive robot in mind

New flexible, movable device with minimally invasive robot in mind

New flexible, movable device with minimally invasive robot in mind

Newswise — The early stage research tested the delivery and safety of the new implantable catheter design in two sheep to determine its potential for use in the diagnosis and treatment of diseases in the brain.

If proven effective and safe for use in people, the platform could simplify and reduce the risks associated with diagnosing and treating disease in deep, delicate parts of the brain.

It can help surgeons look deeper into the brain to diagnose disease, deliver drugs and treatments such as laser ablation more accurately. tumorand better positioning of electrodes for deep brain stimulation in such situations parkinson’s And epilepsy,

senior writer Professor Ferdinando Rodriguez y BaenaImperial’s Mechanical Engineering Departmentled the European effort and said: “The brain is a delicate, complex network of tightly packed nerve cells each with their own role to play. When disease occurs, we can damage those areas without harming healthy cells.” Want to be able to navigate this delicate environment in order to aim accurately.

“Our new precise, minimally invasive platform improves on currently available technology and could enhance our ability to safely and effectively diagnose and treat diseases in people if proven safe and effective.”

developed as part of Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020) Projectpublished in conclusion one more.

stealth surgery

Platform improves on existing minimally invasive, or ‘keyhole’, surgeryWhere surgeons place tiny cameras and catheters through small incisions in the body.

These include a soft, flexible catheter to avoid damaging brain tissue while giving treatment, and an artificial intelligence (AI)-enabled robotic arm to help surgeons navigate the catheter through brain tissue.

Inspired by organs used by parasitic wasps to secretly lay eggs in tree bark, the catheter consists of four interlocking sections that slide over each other to allow flexible navigation.

It connects to a robotic platform that combines human input and machine learning to carefully steer the catheter to the disease site. Surgeons then deliver optical fibers through the catheter so that they can see and navigate the tip along the brain tissue via joystick controls.

The AI ​​platform learns from the surgeon’s input and the contact forces within the brain tissue to guide the catheter with precise precision.

Compared to traditional ‘open’ surgical techniques, the new approach could ultimately help reduce tissue damage during surgery, and improve patient recovery times and post-operative hospital stays.

When performing minimally invasive surgery on the brain, surgeons use deep-penetration catheters to diagnose and treat the disease. However, the catheters currently in use are rigid and difficult to install accurately without the aid of robotic navigational tools. The inflexibility of the catheter, combined with the complex, delicate structure of the brain, means that it can be difficult to place the catheter properly, which brings risks to this type of surgery.

To test their platform, researchers positioned catheters in the brains of two live sheep Milan University‘s Veterinary Complex, The sheep were given pain relief and monitored 24 hours a day for signs of pain or distress prior to euthanasia so that researchers could examine the catheter’s structural effect on brain tissue.

They found no signs of soreness, tissue damage or infection after catheter implantation.

lead author Dr. Ricardo Cicolicalso from Imperial’s Department of Mechanical Engineering, said: “Our analysis has shown that we have safely implanted these new catheters without any damage, infection or pain. If we are to achieve equally promising results in humans, If so, we hope to be able to see this stage in the clinic within four years.

“Our findings may have major implications for minimally invasive, robotically delivered brain surgery. We hope this will help improve the safety and effectiveness of current neurosurgical procedures where precise deployment of treatments and diagnostic systems is needed.” are required, for example in the context of localized gene therapy.

Professor Lorenzo Bellostudy co-author from the University of Milan, said: “One of the major limitations of current MIS is that if you want to move through a burr hole in the skull to a deep-seated position, you have to go straight-forward.” There are constrained-line trajectories. The limitation of the rigid catheter is its accuracy within the transfer tissues of the brain, and the tissue deformation it can cause. Now we have found that our steerable catheter can overcome most of these limitations.”

This study was funded by EU Horizon 2020 Program,

,Modular robotic platform for precision neurosurgery with bio-inspired needles: system overview and first in-vivo deploymentby Ricardo Cecoli, Alois Matheson, Marlene Pinzi, Stefano Galvan, Abdulhamit Dondar, Thomas Watts, Marco Riva, David Zani, Lawrence Bello and Ferdinando Rodriguez and Baena. Published on 19 October 2022 one more.

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